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Phenytoin

Does this test have other names?

Dilantin test

What is this test?

This test monitors the level of the seizure medication phenytoin (Dilantin) in your blood. Phenytoin is an anticonvulsant medication given to control seizures.

Why do I need this test?

If you take phenytoin, your doctor must monitor your blood to make sure you are getting the correct dose. Too much can be toxic. Not enough leaves your seizures uncontrolled.

You may have this test more frequently when you first start taking the drug and then regularly throughout treatment. You may need to repeat the test if the medicine doesn't seem to control your seizures or if any of your other prescription medications change. 

What other tests might I have along with this test?

Your doctor also might order other blood tests, including:

  • Complete blood count

  • Blood urea nitrogen and creatinine test to check kidney function

  • Liver function panel or other liver tests

  • Glucose test to measure your blood sugar, because phenytoin can cause your blood sugar to rise

  • Blood tests to measure the sodium level in your blood

  • Tests for other medicine levels

  • Urinalysis

What do my test results mean?

Many things may affect your lab test results. These include the method each lab uses to do the test. Even if your test results are different from the normal value, you may not have a problem. To learn what the results mean for you, talk with your health care provider.

Results are given in micrograms per milliliter (µ/mL). The normal therapeutic range is 10 to 20 µ/mL. Your doctor will determine the best dose for you based in part on how well your seizures are controlled and how you feel. High levels of phenytoin in your blood can be toxic.

How is this test done?

This test requires a blood sample, which is drawn through a needle from a vein in your arm.

Does this test pose any risks?

Taking a blood sample with a needle carries risks that include bleeding, infection, bruising, or feeling dizzy. When the needle pricks your arm, you may feel a slight stinging sensation or pain. Afterward, the site may be slightly sore.

What might affect my test results?

Adjusting the dosage of any other medication or taking a new medication – prescription or nonprescription – can affect the level of phenytoin in your blood.

Tell your doctor if you are taking any of these drugs:

  • Amiodarone for an irregular heartbeat

  • Chlordiazepoxide or diazepam for anxiety

  • Dicumarol, a blood thinner

  • Disulfiram, to treat alcoholism

  • Estrogens for hormone replacement

  • Aspirin and medications with salicylates

  • Sulfonamides to treat infections

  • Tolbutamide used for diabetes management

  • Famotidine for ulcersIsoniazid, an antibiotic

  • Methylphenidate for attention deficit disorders

  • Phenothiazines for nausea

  • Trazedone for depression and sleep problems

  • Primidone or valproic acid for seizures

  • Fluconazole for yeast infections

Drinking alcohol also can raise the level of phenytoin in your blood. A change in metabolism also can affect your phenytoin levels.

How do I get ready for this test?

You don't need to prepare for this test.  Be sure your doctor knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use. 

Phenytoin - WellSpan Health

Author: Orenstein, Beth W.
Online Medical Reviewer: Fraser, Marianne, MSN, RN
Online Medical Reviewer: Marcellin, Lindsay, MD
Published Date: 2013-02-06T00:00:00
Last Review Date: 2013-02-04T00:00:00
© 2015 WellSpan Health. All Rights Reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.

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